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Purification of the serum acid-stable insulin-like growth factor binding protein from the pig (Sus scrofa)
Authors:P E Walton  R C Baxter  B D Burleigh  T D Etherton
Institution:Department of Dairy and Animal Science, Pennsylvania State University, University Park 16802.
Abstract:1. An acid-stable IGF binding protein was isolated and purified from porcine serum. 2. The protein comprised two major species with Mrs of 45 and 41 kDa determined using SDS-PAGE under reducing conditions. 3. The IGFBP preparation specifically bound both IGF-I and II. 4. Four distinct protein bands (Mrs of 23, 45, 50 and 75 kDa) in the porcine IGFBP preparation specifically bound radiolabelled IGF-I. 5. The porcine IGFBP exhibited sequence homology with IGFBPs from human plasma and rat serum. 6. This is the first report of the purification and characterization of the acid-stable IGFBP from porcine serum.
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