| 模式识别受体-Dectin-1的研究进展 |
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| 引用本文： | 易秀莉,刘斌,齐显龙. 模式识别受体-Dectin-1的研究进展[J]. 中国真菌学杂志, 2012, 7(2): 121-124 |
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| 作者姓名： | 易秀莉 刘斌 齐显龙 |
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| 作者单位： | 第四军医大学西京医院皮肤科,西安,710063 |
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| 基金项目： | 国家自然科学青年基金(31000073) |
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| 摘 要： | Dectin-1是主要表达于髓样细胞中的非Toll样模式识别受体,它能诱导自身胞内信号介导一系列细胞反应,在抗真菌免疫中发挥着重要的作用.该文对Dectin-1介导的信号途径,Dectin-1与其他模式识别受体的相互作用,Dectin-1在适应性免疫、抗微生物免疫中的作用予以综述.
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| 关 键 词： | Dectin-1 信号传导 适应性免疫 抗微生物免疫 |
Recent insights from Dectin-1-Pattern Recognition Receptor |
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| YI Xiu-li,LIU Bin,QI Xian-long. Recent insights from Dectin-1-Pattern Recognition Receptor[J]. Chinese JOurnal of Mycology, 2012, 7(2): 121-124 |
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| Authors: | YI Xiu-li LIU Bin QI Xian-long |
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| Affiliation: | (Department of Dermatology,Xijing Hospital,Fourth Military Medical University,Xi’an 710063,China) |
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| Abstract: | The Dectin-1 is a non-Toll-like pattern recognition receptor expressed predominantly by myeloid cells,which can induce its own intracellular signalling and can mediate a variety of cellular responses,plays a key role in anti-fungal immunity.The recent studies have focused on the signalling pathways from Dectin-1,interactions between Dectin-1 and other PRRs,Dectin-1 and adaptive immunity and the role of Dectin-1 in anti-microbial immunity. |
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| Keywords: | Dectin-1 signalling pathways adaptive immunity anti-microbial immunity |
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