Effects of the non-competitive NMDA receptor antagonist ifenprodil on the morphine-induced place preference in mice |
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Authors: | Suzuki T Kato H Tsuda M Suzuki H Misawa M |
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Institution: | Department of Pharmacology, School of Pharmacy, Hoshi University, Tokyo, Japan. suzuki@hoshi.ac.jp |
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Abstract: | The effects of ifenprodil, a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist, on the morphine-induced place preference were examined in mice. Morphine (1-5 mg/kg, s.c.) produced a dose-related place preference in mice. In contrast, ifenprodil alone (5-20 mg/kg, i.p.) did not produce either preference or aversion for the drug-associated place. Pretreatment with ifenprodil (5-20 mg/kg, i.p.) suppressed the place preference produced by morphine in a dose-dependent manner. These results indicate that ifenprodil suppresses the rewarding effect produced by morphine. |
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