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A genome-wide association study of severe teenage acne in European Americans |
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| Authors: | Mingfeng Zhang Abrar A Qureshi David J Hunter Jiali Han |
| Institution: | 1. Department of Dermatology, Clinical Research Program, Brigham and Women’s Hospital, and Harvard Medical School, 181 Longwood Avenue, Boston, MA, 02115, USA 2. Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital, and Harvard Medical School, Boston, MA, USA 3. Department of Epidemiology, and the Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, MA, USA 4. Department of Epidemiology, Richard M. Fairbanks School of Public Health, Simon Cancer Center, Indiana University, Indianapolis, IN, USA 5. Department of Epidemiology, Cancer Institute and Hospital, Tianjin Medical University, Tianjin, China |
| Abstract: | Despite the family aggregation of severe teenage acne, the genetic basis of this common skin condition remains unclear. We conducted a genome-wide association study (GWAS) on severe teenage acne in 928 European Americans. The SNP rs4133274 on chromosome 8q24 (72 kb upstream of MYC) revealed the most significant association with severe teenage acne (p value = 1.7 × 10?6). The variant allele of this SNP (G allele) was associated with an increased risk of severe teenage acne with odds ratio of 4.01 (95 % confidence interval = 2.37–6.82). Upon further replication, our findings suggest new genetic basis of acne and may explain the association between acne and cancer risk observed in the epidemiological studies. |
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