Histone deacetylase inhibitor activity in royal jelly might facilitate caste switching in bees |
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Authors: | Spannhoff Astrid Kim Yong Kee Raynal Noel J-M Gharibyan Vazganush Su Ming-Bo Zhou Yue-Yang Li Jia Castellano Sabrina Sbardella Gianluca Issa Jean-Pierre J Bedford Mark T |
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Institution: | Department of Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Park Road 1C, Smithville, Texas 78957, USA. |
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Abstract: | Worker and queen bees are genetically indistinguishable. However, queen bees are fertile, larger and have a longer lifespan than their female worker counterparts. Differential feeding of larvae with royal jelly controls this caste switching. There is emerging evidence that the queen-bee phenotype is driven by epigenetic mechanisms. In this study, we show that royal jelly--the secretion produced by the hypopharyngeal and mandibular glands of worker bees--has histone deacetylase inhibitor (HDACi) activity. A fatty acid, (E)-10-hydroxy-2-decenoic acid (10HDA), which accounts for up to 5% of royal jelly, harbours this HDACi activity. Furthermore, 10HDA can reactivate the expression of epigenetically silenced genes in mammalian cells. Thus, the epigenetic regulation of queen-bee development is probably driven, in part, by HDACi activity in royal jelly. |
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