Changes of subcellular localization of Thy-1 antigen during thymic myoid cell differentiation |
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Authors: | Aiko Kikuchi Isao Kamo Kazumi Fujisawa Ikuya Nonaka |
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Affiliation: | (1) National Institute of Neuroscience, NCNP 4-1-1, 187 Ogawahigashi Kodaira Tokyo, Japan |
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Abstract: | Using a quantitative enzyme immunoassay, Thy-1 antigen expressed by a rat myoid cell line R615B2 was detected mainly on the cell surface at a single cell stage, whereas at the stage of forming myotubes, Thy-1 was found predominantly in the cytoplasm. The muscle specific creatine kinase activity also increased in association with the shift of Thy-1 from the cell surface to the cytoplasm, suggesting biological significance of Thy-1 redistribution in muscle differentiation from single cells to multinucleated cells. |
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Keywords: | Thy-1 cytoplasmic Thy-1 enzyme immunoassay quantitative immunohistochemistry thymic myoid cells |
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