| Abstract: | The effect of prostaglandins F2∝, E1 and of 7-oxa-13-prostynoic acid on the newborn rat and rabbit ductus can be studied using the whole-body freezing technique. PGF2∝ and PGE1 were able to re-open the closing ductus arteriosus in adequately oxygenated animals. PGF2∝ administration was accompanied by a strong physical reaction in the rat but less in the rabbit. PGF1 had sedative effects in both animals. A prostaglandin antagonist, 7-oxa-13-prostynoic acid had no effect on normal ductal closure nor did it counteract the effects of PGF2∝ and PGE1. The role of prostaglandins in homeostasis during the fetal and newborn period may be to modify ductal tone. |
