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蓝斑在刺激视上核镇痛中的作用
引用本文:由振东,宋朝佑.蓝斑在刺激视上核镇痛中的作用[J].生理学报,1995,47(4):320-326.
作者姓名:由振东  宋朝佑
作者单位:第二军医大学神经生物学教研室
摘    要:应用核团微量注射、放射免疫测定(RIA)和高压液相(HPLC)观察了刺激视上核(SON)对蓝斑(LC)灌流液中催产素(OT)、精氨酸加压素(AVP)、去甲明上素(NE)和5-羟色胺(5-HT)的含量的变化以及斑注射O笔AVP的拮抗剂对痛阈(PT)的影响。结果表明;刺激SON后30到90min,LC灌流液中OT的含量,30minAVP的含量,60min5-HT的含量明显增加,而NE的含量在30和60

关 键 词:蓝斑  视上核  镇痛

ROLE OF LOCUS COERULEUS IN ANALGESIA CAUSED BY STIMULATION OF SUPRAOPTIC NUCLEUS
YOU ZHEN-DONG,SONG CHAO-YOU,WANG CHEN-HAI,HUANG AI-JUN AND LIN BAO-CHENG.ROLE OF LOCUS COERULEUS IN ANALGESIA CAUSED BY STIMULATION OF SUPRAOPTIC NUCLEUS[J].Acta Physiologica Sinica,1995,47(4):320-326.
Authors:YOU ZHEN-DONG  SONG CHAO-YOU  WANG CHEN-HAI  HUANG AI-JUN AND LIN BAO-CHENG
Abstract:The effects of stimulation of supraoptic nucleus (SON) on the changes of oxytocin (OT), arginine vasopressin (AVP), norepinephrine (NE) and serotonin (5-HT) in the perfusate of locus coeruleus (LC) and changes of pain threshild (PT) were studied by methods of microinjection, radioimmunoassay (RIA) and high pressure liquid chromatography (HPLC) technique. The results showed that the OT contentS at 30, 60 and 90 min after stimulation, that of AVP at 30 min and 5-HT at 60 min were increased significantly, while the NE contents at 30 and 60 min were decreased markedly, Injection of V1 antagonist into LC did not affect the analgesic effect caused by administration of L-glutamic acid (L-Glu) into SON, which, however, could be partially inhibited by V2 antagonist or even reversed by OT antagonist. The above results suggested that the analgesic effect due to stimulation of SON is caused by increase of 5-HT and decreases of NE in the LC though the action of OT released by SON on OT and V2 receptor in LC.
Keywords:locus coeruleus  supraoptic nucleus  oxytocin  serotonin  norepinephrine  analgesia  rat  
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