Developmental changes in the activities of enzymes related to methyl group metabolism in sheep tissues |
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Authors: | G P Xue A M Snoswell |
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Affiliation: | 1. Department of Veterinary Sciences, Polo Universitario dell'' Annunziata, University of Messina, 98168 Messina, Italy;2. Department of Biological and Environmental Sciences, Viale Ferdinando Stagno d''Alcontres 31, University of Messina, 98166 S. Agata-Messina, Italy;1. Department of Physiology, University of Louisville, KY, USA;2. Department of Medicine, University of Louisville, KY, USA;3. Robley Rex VA Medical Center, Louisville, KY, USA;4. Department of Physiology and Biophysics, Howard University College of Medicine, Washington, DC, USA |
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Abstract: | The activities of choline oxidase and betaine-homocysteine methyltransferase increased markedly in pre-ruminant lamb liver after birth and subsequently decreased when the lambs reached the ruminant state, while the developmental changes in hepatic 5-methyl-H4folate-homocysteine methyltransferase were negatively correlated with those of betaine-homocysteine methyltransferase. Hepatic phospholipid methyltransferase was elevated almost four-fold by the 10th postnatal day, but declined thereafter. Hepatic glycine methyltransferase in one-day-old lambs increased 55-fold, compared with that of fetuses, and thereafter decreased dramatically with age. Guanidoacetate methyltransferase, glycine methyltransferase and betaine-homocysteine methyltransferase in sheep pancreas increased markedly with age and were many times higher than the hepatic enzymes in adult sheep. Choline oxidase, betaine-homocysteine methyltransferase, cystathionine beta-synthase and glycine methyltransferase in adult sheep liver were much lower than those in rat. These results illustrate the conservative features of methyl group metabolism in postruminant sheep. |
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