Downregulation of messenger RNA levels for ribosomal proteins in differentiating HL-60 cells. |
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| Authors: | R Mailhammer H Sz?ts J B?nisch P D?rmer |
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| Affiliation: | GSF-Institut für Experimentelle H?matologie, München, Germany. |
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| Abstract: | After differentiation induction in HL-60 cells by treatment with retinoic acid, phorbol ester, or dimethyl sulfoxide strong downregulation of the steady state mRNA level of the putative protein No. 3 of the large ribosomal subunit (rpL3) was observed. Downregulation was also observed in other hemopoietic human cell lines, although to a lesser extent. Four ribosomal protein mRNAs were compared in their degree of downregulation after differentiation induction or actinomycin D treatment. The comparatively fast response of rpL3 mRNA observed could indicate a regulatory function of rpL3 protein. |
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