|
|||||
|
|
Identification of a prealbumin variant in the serum of a Japanese patient with familial amyloidotic polyneuropathy |
|
| Authors: | M Nakazato K Kangawa N Minamino S Tawara H Matsuo S Araki |
| Institution: | 1. Medical Research Council Mechanisms of Drug Toxicity Research Group Department of Pharmaceutical Sciences, University of Aston in Birmingham, Birmingham B4 7ET, U.K.;2. Cancer Research Campaign Experimental Chemotherapy Research Group, Department of Pharmaceutical Sciences, University of Aston in Birmingham, Birmingham B4 7ET, U.K. |
| Abstract: | Serum prealbumin isolated from a Japanese patient with familial amyloidotic polyneuropathy (FAP) has been found to consist of a mixture of normal prealbumin and a prealbumin variant which contains a methionine for valine substitution at position 30. The prealbumin variant in the serum is identical to the prealbumin variant derived from amyloid fibrils of a Japanese FAP patient. FAP likely results from the deposition of abnormal serum prealbumin in various organs as amyloid fibrils. |
| Keywords: | carbon tetrachloride DMF N N-dimethylformamide F formamide HMF N-hydroxymethylformamide NMF N-methylformamide triphenylmethylphosphonium |
| 本文献已被 ScienceDirect 等数据库收录！ | |