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The role of chemokine and chemokine receptor gene variants on the susceptibility and clinicopathological characteristics of bladder cancer |
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| Authors: | Canan Kucukgergin Ferruh K Isman Selcuk Dasdemir Bedia Cakmakoglu Oner Sanli Cahide Gokkusu Sule Seckin |
| Institution: | 1. Department of Biochemistry, Istanbul Faculty of Medicine, Istanbul University, Istanbul, 34093, Turkey;2. Goztepe Teaching and Research Hospital, Clinical Biochemistry Laboratory, Istanbul, Turkey;3. Department of Molecular Medicine, Institute for Experimental Medicine Research, Istanbul University, Istanbul, 34093 Turkey;4. Department of Urology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, 34093, Turkey |
| Abstract: | The gene variants of the chemokine and chemokine receptor genes associated with inflammation may be involved in cancer initiation and progression. The aim of this study was to explore the possible association of monocyte chemoattractant protein-1 (MCP-1) A2518G, stromal cell derived factor 1 (SDF-1) 3′A and chemokine receptors CCR2A V64I, CCR5 Δ32, CCR5 59029 and CXCR4 gene polymorphisms with the risk and clinicopathological characteristics of bladder cancer (BC) in a Turkish population. |
| Keywords: | BC bladder cancer MCP-1 monocyte chemoattractant protein-1 SDF-1 stromal cell derived factor-1 SNP single nucleotide polymorphism TCC transitional cell carcinoma TNM tumor-node-metastasis PCR polymerase chain reaction RFLP Restriction Fragment Length Polymorphism CCR2 CC chemokine receptor 2 CCR5 CC chemokine receptor 5 CXCR4 chemokine receptor 4 |
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