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Association between chemerin rs17173608 and vaspin rs2236242 gene polymorphisms and the metabolic syndrome,a preliminary report |
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| Authors: | Mohammad Hashemi Hamzeh Rezaei Ebrahim Eskandari-Nasab Mahmoud Ali kaykhaei Zahra Zakeri Mohsen Taheri |
| Institution: | 1. Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran;2. Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran;3. Department of Internal Medicine, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran;4. Genetic of Non Communicable Disease Research Center, Zahedan University of Medical Science, Zahedan, Iran |
| Abstract: | Metabolic syndrome (MeS) is associated with increased risk for type 2 diabetes mellitus (T2DM) and cardiovascular disease. There is some evidence indicating that adipokines play a role in the development of MeS. The present study was aimed to investigate the impact of chemerin rs17173608 and vaspin rs2236242 gene polymorphisms with the risk of MeS in a sample of Iranian population. |
| Keywords: | ACE Angiotensin-1-converting enzyme AHA/NHLBI American Heart Association/National Heart Lung and Blood Institute BMI body mass index CIDEA cell death-inducing DNA fragmentation factor alpha-like effector A CMKLR1 chemokine-like receptor 1 CI confidence intervals eNOS endothelial nitric oxide synthase HOMA-IR homeostasis model assessment estimated-insulin resistance IDF international diabetes federation MeS metabolic syndrome NCBI National Center for Biotechnology Information NCEP-ATP III national cholesterol education program-adult treatment panel III OR odds ratio PON paraoxonase PCR polymerase chain reaction T2DM type 2 diabetes mellitus VAT visceral adipose tissue WHR waist to hip ratio |
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