Meta-analysis on association between the ATP-binding cassette transporter A1 gene (ABCA1) and Alzheimer's disease |
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Authors: | Mei Jiang Lei Lv Hairong Wang Xuelian Yang Haifeng Ji Fei Zhou Wei Zhu Liying Cai Xiaju Gu Jian Sun Qiang Dong |
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Institution: | 1. Department of Neurology, Shanghai Pudong New Area Gongli Hospital, 219 Miao Pu Road, Shanghai 200135, PR China;2. Department of Neurology, Huashan Hospital, Fudan University, Shanghai 200042, PR China;3. Department of Cardiology, Shanghai Pudong New Area Gongli Hospital, 219 Miao Pu Road, Shanghai 200135, PR China |
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Abstract: | PurposeIn the past decade, a number of case–control studies have been carried out to investigate the relationship between ABCA1 polymorphisms and Alzheimer's disease (AD). However, these studies have yielded contradictory results. To investigate this inconsistency, a meta-analysis was performed.MethodsDatabases including PubMed, Web of Science, EMBASE and CNKI were searched to find relevant studies. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association.ResultsA total of 13 case–control studies, involving 6214 patients and 6034 controls for ABCA1 polymorphisms were included. In a combined analysis, the summary per-allele odds ratio for AD of the 219 K was 1.03 (95% CI: 0.93–1.14, p = 0.56). A meta-analysis of studies on the 883 M and 1587 K variant showed no significant overall association with AD, yielding a per-allele odds ratio of 1.10 (95% CI: 0.96–1.26, p = 0.16), and 1.09 (95% CI: 0.97–1.24, p = 0.16) respectively. Similar results were also found for heterozygous and homozygous. In the subgroup analysis by ethnicity, sample size, APOE status and onset type, no significant associations were found in almost all genetic models.ConclusionsIn summary, there was no significant association detected between ABCA1 R219K, I883M and R1587K polymorphisms and risk for AD. |
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Keywords: | AD Alzheimer's disease ABCA1 ATP-binding cassette transporter A1 Aβ Amyloid beta CI Confidence interval EOAD Early onset Alzheimer's disease LOAD Late onset Alzheimer's disease HWE Hardy&ndash Weinberg equilibrium OR Odds ratio |
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