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Gene expression profiles displayed by peripheral blood mononuclear cells from patients with type 2 diabetes mellitus focusing on biological processes implicated on the pathogenesis of the disease |
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| Authors: | Fernanda S. Manoel-Caetano Danilo J. Xavier Adriane F. Evangelista Paula Takahashi Cristhianna V. Collares Denis Puthier Maria C. Foss-Freitas Milton C. Foss Eduardo A. Donadi Geraldo A. Passos Elza T. Sakamoto-Hojo |
| Affiliation: | 1. Department of Biology, Faculty of Philosophy, Sciences and Letters of Ribeirão Preto, University of São Paulo — USP, Ribeirão Preto, SP, Brazil;2. Department of Genetics, Faculty of Medicine of Ribeirão Preto, University of São Paulo — USP, Ribeirão Preto, SP, Brazil;3. Inserm U928, TAGC, Aix–Marseille Université IFR137, Marseille, France;4. Department of Medical Clinic, Faculty of Medicine of Ribeirão Preto, University of São Paulo — USP, Ribeirão Preto, SP, Brazil;5. Department of Morphology, Stomatology, and Physiology, School of Dentistry of Ribeirão Preto, University of São Paulo — USP, Ribeirão Preto, SP, Brazil |
| Abstract: | |
| Keywords: | BMI, body mass index FA, fatty acid FC, fold-change FFA, free fatty acid GO, gene ontology GSA, gene set analysis HbA1c, glycated hemoglobin IGA, individual gene analysis IKK, I-kappa-B kinase IL, interleukin IRS, insulin receptor substrate JNK, c-jun N-terminal kinase NF-κB, nuclear factor-kappa B OGTT, oral glucose tolerance test OXPHOS, oxidative phosphorylation PBMC, peripheral blood mononuclear cell PCNA, proliferating cell nuclear antigen RIN, RNA integrity number ROS, reactive oxygen species SOCs, suppressors of cytokine signaling T2DM, type 2 diabetes mellitus TLR, toll-like receptor TNFα, tumor necrosis factor-alpha |
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