Association of P213S polymorphism of the L-selectin gene with type 2 diabetes and insulin resistance in Chinese population |
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Authors: | Jing Liu Ju-xiang Liu San-ni Xu Jin-xing Quan Li-min Tian Qian Guo Jia Liu Yun-fang Wang Zhi-yong Shi |
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Affiliation: | 1. Department of Endocrinology, Gansu Provincial People''s Hospital, 204 West Donggang Road, Lanzhou City 730000, Gansu Province, China;2. The First People''s Hospital of Tianshui City, Tianshui City 741000, Gansu Province, China;3. The First Clinical College of Lanzhou University, Lanzhou City 730000, Gansu Province, China |
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Abstract: | AimsL-selectin belongs to selectin family of adhesion molecule and participates in the generation and development of type 2 diabetes (T2D). In this study, we evaluated the relationship between the P213S polymorphism of L-selectin gene and T2D and insulin resistance in the Chinese population.MethodsWe genotyped P213S polymorphism in 801 patients with T2D and 834 healthy controls in the Chinese population using polymerase chain reaction–ligase detection reaction (PCR–LDR) technique. Plasma glucose, insulin, lipid, blood urea nitrogen, creatinine and uric acid levels were measured by biochemical technique.ResultsThe frequency of 213PP genotype and P allele of the L-selectin gene in patients with T2D was significantly higher than that in controls (P = 0.007; P = 0.019, respectively). The relative risk of allele P suffered from T2D was 1.191 times higher than that of allele S. Moreover, the levels of FPG and HOMA-IR of PP and PS genotype carriers were significantly higher than those of SS genotype carriers in the T2D group (P < 0.05).ConclusionThese findings indicated that the P213S polymorphism of L‐selectin gene may contribute to susceptibility to T2D and insulin resistance in the Chinese population, and P allele appears to be a risk factor for T2D. |
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Keywords: | T2D, type 2 diabetes PCR&ndash LDR, polymerase chain reaction&ndash ligase detection reaction SCR, short consensus repeat CAD, coronary artery disease SMI, silent myocardial ischemia GD, Graves' disease T1D, Type 1 diabetes WHO, World Health Organization TC, total cholesterol TG, triglyceride HDL-C, high density lipoprotein-cholesterol LDL-C, low density lipoprotein-cholesterol BMI, body mass index WHR, waist hip ratio FPG, fasting plasma glucose FINS, fasting insulin HOMA-IRI, insulin resistance index HOMA-IR, homeostasis model assessment of insulin resistance OR, odds ratios CI, confidence intervals SBP, systolic blood pressure DBP, diastolic blood pressure BUN, blood urea nitrogen CR, creatinine UA, uric acid |
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