ACL/MCL transection affects knee ligament insertion distance of healing and intact ligaments during gait in the Ovine model |
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Authors: | Janet E Tapper Yusei Funakoshi Mitsuhiro Hariu Linda Marchuk Gail M Thornton Janet L Ronsky Ron Zernicke Nigel G Shrive Cyril B Frank |
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Institution: | 1. Orthopedic Surgery, Hospital for Special Surgery, 535 E 71st, New York 10021, NY, USA;2. Radiology Department, Hospital Clinico San Carlos, Calle Prof Martín Lagos S/N, 28040 Madrid, Spain;3. Surgery Department, Facultad de Veterinaria Universidad de Leon, Facultad de Veterinaria, 25, 24004 León, Spain;4. Orthopedic Department, Hospital Greogorio Marañon, Calle del Dr. Esquerdo, 46, 28007 Madrid, Spain;5. School of Medicine, Universidad San Pablo CEU, Ctra. Boadilla del Monte, Km. 5 300, 28925 Alcorcon, Madrid, Spain;1. From the Department of Physical Examination, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China;2. Division of Medical Statistics, School of Public Health and Management, Chongqing Medical University, Chongqing, China;3. Department of Endocrinology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China. |
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Abstract: | The objective of this study was to assess the impact of combined transection of the anterior cruciate and medial collateral ligaments on the intact and healing ligaments in the ovine stifle joint. In vivo 3D stifle joint kinematics were measured in eight sheep during treadmill walking (accuracy: 0.4±0.4 mm, 0.4±0.4°). Kinematics were measured with the joint intact and at 2, 4, 8, 12, 16 and 20 weeks after either surgical ligament transection (n=5) or sham surgery without transection (n=3). After sacrifice at 20 weeks, the 3D subject-specific bone and ligament geometry were digitized, and the 3D distances between insertions (DBI) of ligaments during the dynamic in vivo motion were calculated. Anterior cruciate ligament/medial collateral ligament (ACL/MCL) transection resulted in changes in the DBI of not only the transected ACL, but also the intact lateral collateral ligament (LCL) and posterior cruciate ligament (PCL), while the DBI of the transected MCL was not significantly changed. Increases in the maximal ACL DBI (2 week: +4.2 mm, 20 week: +5.7 mm) caused increases in the range of ACL DBI (2 week: 3.6 mm, 20 week: +3.8 mm) and the ACL apparent strain (2 week: +18.9%, 20 week: +24.0%). Decreases in the minimal PCL DBI (2 week: −3.2 mm, 20 week: −4.3 mm) resulted in increases in the range of PCL DBI (2 week: +2.7 mm, 20 week: +3.2 mm). Decreases in the maximal LCL DBI (2 week: −1.0 mm, 20 week: −2.0 mm) caused decreased LCL apparent strain (2 week: −3.4%, 20 week: −6.9%). Changes in the mechanical environment of these ligaments may play a significant role in the biological changes observed in these ligaments. |
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Keywords: | Ovine In vivo Kinematics Knee Ligament |
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