Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21 |
| |
| Authors: | Inagaki Takeshi Dutchak Paul Zhao Guixiang Ding Xunshan Gautron Laurent Parameswara Vinay Li Yong Goetz Regina Mohammadi Moosa Esser Victoria Elmquist Joel K Gerard Robert D Burgess Shawn C Hammer Robert E Mangelsdorf David J Kliewer Steven A |
| |
| Affiliation: | Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. |
| |
| Abstract: | Peroxisome proliferator-activated receptor α (PPARα) regulates the utilization of fat as an energy source during starvation and is the molecular target for the fibrate dyslipidemia drugs. Here, we identify the endocrine hormone fibroblast growth factor 21 (FGF21) as a mediator of the pleiotropic actions of PPARα. FGF21 is induced directly by PPARα in liver in response to fasting and PPARα agonists. FGF21 in turn stimulates lipolysis in white adipose tissue and ketogenesis in liver. FGF21 also reduces physical activity and promotes torpor, a short-term hibernation-like state of regulated hypothermia that conserves energy. These findings demonstrate an unexpected role for the PPARα-FGF21 endocrine signaling pathway in regulating diverse metabolic and behavioral aspects of the adaptive response to starvation. |
| |
| Keywords: | HUMDISEASE |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
