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'Reverse' alpha-ketoamide-based p38 MAP kinase inhibitors |
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| Authors: | Montalban Antonio Garrido Boman Erik Chang Chau-Dung Ceide Susana Conde Dahl Russell Dalesandro David Delaet Nancy G J Erb Eric Gibbs Andrew Kahl Jeff Kessler Linda Lundström Jan Miller Stephen Nakanishi Hiroshi Roberts Ed Saiah Eddine Sullivan Robert Wang Zhijun Larson Christopher J |
| Institution: | Drug Discovery, Kemia, Inc., 5871 Oberlin Drive, Suite 100, San Diego, CA 92121, USA. catalaba@hotmail.com |
| Abstract: | We have identified a second series of potent p38 inhibitors. As with our first generation series, these compounds are based on an alpha-ketoamide scaffold. The reversal of the ketoamide order, however, introduces more chemical flexibility and in addition results in improve potencies against p38. |
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