Age impairs Flk-1 signaling and NO-mediated vasodilation in coronary arterioles |
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| Authors: | LeBlanc Amanda J Shipley Robert D Kang Lori S Muller-Delp Judy M |
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| Institution: | Center for Interdisciplinary Research in Cardiovascular Sciences, Department of Physiology and Pharmacology, P.O. Box 9105, 1 Medical Center Dr., West Virginia University School of Medicine, Morgantown, WV 26506, USA. |
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| Abstract: | Impairment of flow-induced vasodilation in coronary resistance arterioles may contribute to the decline in coronary vasodilatory reserve that occurs with advancing age. This study investigated the effects of age on flow-induced signaling and activation of nitric oxide (NO)-mediated vasodilation in coronary resistance arterioles. Coronary arterioles were isolated from young (approximately 6 mo) and old (approximately 24 mo) male Fischer-344 rats to assess vasodilation to flow, vascular endothelial growth factor (VEGF), and ACh. Flow- and VEGF-induced vasodilation of coronary arterioles was impaired with age (P
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