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Effects of Panax ginseng on the nerve growth factor expression in testosterone induced benign prostatic hyperplasia
Authors:Su Kang Kim  Il GyuKo  Hae Jeong Park  Joo-Ho Chung  Kyu Bong Cho  Oh Young Kwon  Kyeong Hun Park  Young Sub Ahn  Chun Geon Park  Young Ock Kim
Affiliation:1. Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea;2. Department of Physiology, School of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea;3. Department of Biomedical Laboratory Science, College of Health Sciences, Shinhan University, Gyeonggi 11644, Republic of Korea;4. Department of Medical Education and Medical Humanities, School of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea;5. Herbal Crop Utilization Research Team, Department of Medicinal Crop Research Institute, Republic of Korea
Abstract:The prostatic hyperplasia in benign prostatic hyperplasia (BPH) leads to obstructive micturition symptoms. Previous studies showed that pontine micturition center (PMC), ventrolateral periaqueductal gray (vlPAG), and medial preopticnucleus (MPA) regions in the brain have been known to regulate the urinary bladder function. The present study shows the influences of Panax ginseng on nerve growth factor (NGF) expressions in PMC, vlPAG, and MPA regions in the brain. Wistar rats were used for the present study. The rats split into four groups; 4 groups (n = 6) in control group, BPH-induced group, BPH-induced and P. ginseng-treated group, and BPH-induced and finasteride-treated group. BPH in rats was induced by testosterone and the animals were evaluated for NGF expression in PMC, vlPAG, and MPA regions in the brain. The NGF expression was identified using immunohistochemistry (IHC). The NGF expression by IHC showed spots with dark brown color. In our results, NGF expressions in PMC, vlPAG, and MPA regions in the brainstem of the BPH-induced group showed increase than the control animal. These increased NGF expressions in three regions were decreased using treatment with P. ginseng (200 mg/kg). These results suggest that P. ginseng has therapeutic effects on the symptoms of BPH and is associated with the regulation of NGF expression in the brain. In conclusion, the administration of P. ginseng helps nerve growth factor activation.
Keywords:Benign prostatic hyperplasia  NGF  Brain
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