MicroRNA-4728 mediated regulation of MAPK oncogenic signaling in papillary thyroid carcinoma |
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Authors: | Zhibao Liu Jinghua Zhang Jinghua Gao Yunnan Li |
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Institution: | 1. Hebei Cangzhou Central Hospital, Cangzhou 061001, PR China;2. Massey University, Private Bag 11, 222 Palmerston North, 4442, New Zealand |
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Abstract: | Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer that accounts for 85% of thyroid cancers. MicroRNAs (miRNAs) have been reported to play important roles in the biological processes in cancer. In this study, we analyzed the biological role of miR-4728 in human PTC process in human PTC cell lines in vitro. MiRNA-4728 was observed to down-regulated in human PTC tissues and PTC cell lines. Additionally, miR-4728 inhibited PTC cell proliferation. Further study demonstrated SOS1 was repressed by miR-4728 and overexpression of miR-4728 down-regulated both the mRNA and protein levels of SOS1. Moreover, miR-4728 overexpression also decreased the MAPK signaling activity. These observations suggested that miR-4728 could inhibit the process of human PTC through regulating MAPK signaling pathway. And, appropriate regulation of miR-4728 might be vital to improve human PTC treatment. |
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Keywords: | microRNA-4728 (miR-4728) Papillary thyroid carcinoma SOS1 Cell proliferation |
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