Activation of polyamine biosynthetic decarboxylases during the acute phase response of rat liver |
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| Authors: | G Scalabrino M E Ferioli R Piccoletti A Bernelli-Zazzera |
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| Affiliation: | 1. School of Mechanical and Electrical Engineering, University of Electronic Science and Technology of China, Chengdu, 611731, China;2. INEGI & CONSTRUCT, Faculty of Engineering, University of Porto, Porto, 4200-465, Portugal;3. Faculty of Civil Engineering and Geosciences, Delft University of Technology, Delft, 2628 CN, Netherlands;4. Institute of Electronic and Information Engineering of UESTC in Guangdong, Dongguan, 523808, China;5. Department of Mechanical and Industrial Engineering, Norwegian University of Science and Technology, Trondheim, 7491, Norway;1. Department of Chemistry, Faculty of Sciences, University of Zabol, Zabol, Iran;2. Malek-Ashtar University of Technology, Tehran, Iran;1. International Management Institute, Kolkata, India;2. University of Puerto Rico, San Juan, PR, USA;3. University of Reading Henley Business School, UK;1. Economics College, Zhongnan University of Economics and Law, Nanhu Avenue NO.182, Wuhan, Hubei, 430073, China;2. Department of Public and International Affairs, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, China;3. Shenzhen Research Institute, City University of Hong Kong, Shenzhen, 518057, China;4. School of Economics and Management, Southeast University, Nanjing, 211189, China;5. College of Economics and Management, Nanjing Forestry University, Nanjing, 210037, China;1. Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India;2. Microbiology & Fermentation Technology Department, CSIR-Central Food Technological Research Institute, Mysore, Karnataka, India;1. Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi''an, Shaanxi 710127, China;2. School of Chemical Engineering, Northwest University, Xi''an, Shaanxi 710069, China;3. School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore |
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| Abstract: | The activities of ornithine decarboxylase and S-adenosylmethionine decarboxylase increase in the livers of rats during the acute-phase response to inflammation. The increase reaches its maximum at 2.5 hr from injection of turpentine, and is maintained at the same level for the following 2 days. Pretreatment in vivo with an inhibitor of cyclooxygenase prevents the inflammation-associated increases of both polyamine biosynthetic decarboxylases: an inhibitor of the lipoxygenase pathway seems to counteract only the increase of ornithine decarboxylase. The administration of diaminopropane, an inhibitor of ornithine decarboxylase, has only limited effects on the activation of RNA synthesis by liver nuclei, which occurs 10 hr after turpentine treatment. The results suggest that stimulation of the polyamine biosynthetic decarboxylases is surely part of the acute-phase response and depends on the previous activation of arachidonate metabolism: however its role in supporting later events of the acute-phase response will need further investigations. |
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