Multitracer Screening: Brain Delivery of Trace Elements by Eight Different Administration Methods |
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Authors: | Yousuke?Kanayama Takae?Tsuji Shuichi?Enomoto Email author" target="_blank">Ryohei?AmanoEmail author |
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Institution: | (1) School of Health Sciences, Faculty of Medicine, Kanazawa University, Ishikawa 920-0942, Japan;(2) RIKEN, The Institute of Physical and Chemical Research, Saitama 351-0198, Japan |
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Abstract: | Trace elements are closely associated with the normal functioning of the brain. Therefore, it is important to determine how
trace elements enter, accumulate, and are retained in the brain. Using the multitracer technique, which allows simultaneous
tracing of many elements and comparison of their behavior under identical experimental conditions, we examined the influence
of different administration methods, i.e., intravenous (IV), intraperitoneal (IP), intramuscular (IM), subcutaneous (SC),
intracutaneous (IC), intranasal (IN), peroral (PO), and percutaneous (PC) administration, on the uptake of trace elements.
A multitracer solution containing 16 radionuclides (i.e., 7Be, 46Sc, 48V, 51Cr, 54Mn, 59Fe, 56Co, 65Zn, 74As, 75Se, 83Rb, 85Sr, 88Y, 88Zr, 95mTc, and 103Ru) was used. The results indicated that the 83Rb brain uptake rate with intranasal administration was approximately twice those obtained with the other administration methods.
This result indicated that a portion of Rb was delivered into the brain circumventing the blood circulation and that delivery
could be accomplished mainly by olfactory transport. Multitracer screening of trace element delivery revealed differences
in brain uptake pathways among administration methods. |
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Keywords: | brain delivery multitracer trace element |
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