Induction of second trimester abortion: Comparison between vaginal 15-methyl-PGF2α methyl ester and intra-amniotic PGF2α |
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Authors: | M. Mandelin P. Kajanoja |
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Affiliation: | Second Department of Obstetrics and Gynaecology, University Central Hospital, SF-00290 Helsinki 29, Finland |
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Abstract: | The efficiency and acceptability of a single-dose, long-acting vaginal suppository containing 3.0 mg of 15-methyl PGF2α methyl ester was compared with intra-amniotic administration of 50 mg of PGF2α in 100 patients with a second trimester pregnancy termination. Within 24 hours, 78 per cent of the patients in the vaginal group and 92 per cent in the intra-amniotic group had aborted. The mean induction-abortion interval was 17.9 hours in the vaginal group and 15.8 hours in the intra-amniotic group.Gastrointestinal side-effects were more frequent, but the procedure was less painful, with vaginal 15-methyl PGF2α methyl ester than with intra-amniotic PGF2α.The vaginal route is technically simple for adaptation to large-scale use, but the high frequency of gastrointestinal side-effects still limits the acceptability of 15-methyl PGF2α methyl ester in vaginal administration. |
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