Dietary Taurine Supplementation Ameliorates Diabetic Retinopathy via Anti-excitotoxicity of Glutamate in Streptozotocin-induced Sprague-Dawley Rats |
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Authors: | Xiaoping Yu Zhaoxia Xu Mantian Mi Hongxia Xu Jundong Zhu Na Wei Ka Chen Qianyong Zhang Kaihong Zeng Jian Wang Fang Chen Yong Tang |
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Affiliation: | (1) Department of Public Health, School of Preclinical Medicine, Chengdu Medical College, 601 Rongdu Road, Jinniu District, Chengdu, 610081, China;(2) Department of Nutrition and Food Hygiene, School of Preventive Medicine, The Third Military Medical University, 30 Gaotanyan Street, Shapingba District, Chongqing, 400038, China;(3) Department of Nutrition, Xinqiao Hospital, The Third Military Medical University, 30 Gaotanyan Street, Shapingba District, Chongqing, 400038, China |
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Abstract: | The purpose of this study was to investigate whether taurine ameliorate the diabetic retinopathy, and to further explore the underlying mechanisms. The Sprague-Dawley rats were injected with streptozotocin to establish experimental diabetic model, then fed without or with 1.2% taurine for additional 4–12 weeks. After that, the protective effects of dietary taurine supplementation on diabetic retinopathy were estimated. Our results showed that chronic taurine supplement effectively improved diabetic retinopathy as changes of histopathology and ultrastructure. The supplementation could not lower plasma glucose concentration (P > 0.05), but caused an elevation in taurine content and a decline in levels of glutamate and γ-aminobutyric acid (GABA) in diabetic retina (P < 0.05). Moreover, chronic taurine supplementation increased glutamate transporter (GLAST) expression (P < 0.05), decreased intermediate filament glial fibrillary acidic protein (GFAP) and N-methyl-d-aspartate receptor subunit 1 (NR1) expression in diabetic retina (P < 0.05). These results demonstrated that chronic taurine supplementation ameliorates diabetic retinopathy via anti-excitotoxicity of glutamate in rats. |
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Keywords: | Taurine Diabetic retinopathy Glutamate Glutamate transporter Glial fibrillary acidic protein N-methyl- font-variant:small-caps" >d-aspartate receptor subunit 1 |
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