Selenium and zinc levels in volatile substance abusers |
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Authors: | Dündaröz M Ru?en Türkbay Tümer Sarici S Umit Akay Cemal Sayal Ahmet Denli Metin |
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Institution: | (1) Department of Pediatrics, Gülhane Military Medical Academy, Ankara, Turkey;(2) Child Psychiatry, Gülhane Military Medical Academy, Ankara, Turkey;(3) Pharmaceutical Sciences, Gülhane Military Medical Academy, Ankara, Turkey;(4) Department of Health, Administration of the Turkish Army, Ankara, Turkey |
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Abstract: | Plasma and erythrocyte levels of selenium (Se) and zinc (Zn) have not been investigated in volatile (inhalant) substance abusers
previously, although changes in the activities of antioxidant enzymes resulting from oxidative damage caused by various constituents
of volatile substances have been shown in a few animal and human studies. Concentrations of these two elements in erythrocytes
and plasma of 37 adolescents with inhalant abuse were measured by atomic absorption spectrophotometry and compared with those
of 37 age-matched healthy controls. Erythrocyte and plasma levels of Se and plasma level of Zn were significantly lower in
the study group when compared to the control group. Chronic inhalation of volatile substances can decrease the plasma levels
of Se and Zn and, thus, may lead to a decrease in the activity of antioxidant enzyme systems in adolescent abusers. The role
of Se and Zn supplementation in children with inhalant abuse remains to be determined considering the reduced antioxidant
activity resulting from deficiency of these trace elements. |
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Keywords: | Adolescent glue inhalant abuse selenium thinner volatile substance zinc |
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