| 应用Vero细胞检定法和家兔皮内中和法检测吸附白喉类毒素的效价 |
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| 引用本文： | 戎奋生,张伟平.应用Vero细胞检定法和家兔皮内中和法检测吸附白喉类毒素的效价[J].微生物学免疫学进展,1997(3). |
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| 作者姓名： | 戎奋生 张伟平 |
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| 作者单位： | 卫生部北京生物制品研究所 |
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| 摘 要： | Ｖｅｒｏ细胞法测定ＤＴＰ疫苗中白喉类毒素的效价与家兔皮内中和法（简称ＮＴ法）所得结果两法之间有一种平行关系，并且有很好的相关性，ｒ＝０．９３。但Ｖｅｒｏ细胞法测得平均值低于ＮＴ法，二者之间的平均比率为０．２８７，Ｓ＝０．０８９。本试验结果与１９９５部颁规程ＮＴ法０．２５ＩＵ／ｍｌ相比，确定了Ｖｅｒｏ细胞法以０．０７ＩＵ／ｍｌ作为检定吸附ＤＴＰ效价的最低要求。
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| 关 键 词： | Vero细胞 家兔皮内中和试验 抗体效价 |
The Potency Test of Diphtheria Tioxoid in DTP Using Vero cell Method and Rabbit Skin Neutralization Test |
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| Rong Fensheng,et al National Vaccine and Serum Institute Beijing.The Potency Test of Diphtheria Tioxoid in DTP Using Vero cell Method and Rabbit Skin Neutralization Test[J].Progress In Microbiology and Immunology,1997(3). |
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| Authors: | Rong Fensheng National Vaccine and Serum Institute Beijing |
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| Institution: | Rong Fensheng,et al National Vaccine and Serum Institute Beijing 100024 |
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| Abstract: | The diphtheria antitoxin titre of guinea pigs immunized with DTP Vaccine were detected by vero cell method and compared with those by rabbit skin neutralization test.The result showed good correlation between them,r=0.93.But the mean titre of diphtheria antitoxin detected by vero cell method were lower than those obtained by rabbit skin neutraliztion test.The mean titre ratio of Vero cell and NT method was 0.287. |
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| Keywords: | Vero cell Rabbit skin neutralization test Antitoxin titre |
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