| 合欢皮提取物抑制血管生成作用的研究 |
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| 引用本文： | 花慧,冯磊,张小平,张莲芬,金坚.合欢皮提取物抑制血管生成作用的研究[J].天然产物研究与开发,2010,22(2):215-218. |
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| 作者姓名： | 花慧 冯磊 张小平 张莲芬 金坚 |
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| 作者单位： | 1. 江南大学医药学院天然药物研究室
2. 江南大学工业生物技术教育部重点实验室,无锡,214122 |
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| 基金项目： | 教育部博士点新教师基金 |
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| 摘 要： | 本文采用体外细胞培养法和体内鸡胚尿囊绒膜模型、荷瘤模型检测合欢皮提取物抑制人微血管内皮细胞(HMEC-1)的增殖、迁移活性,观察合欢皮提取物的抑制血管生成情况。发现合欢皮提取物能显著抑制HMEC-1的增殖(IC50为30μg/mL)和迁移,并且呈明显的剂量依赖性。在体内同时具有抑制鸡胚尿囊膜和肿瘤组织中血管生成的作用。
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| 关 键 词： | 合欢皮 血管生成 内皮细胞 |
The Study on the Anti-angiogenenic Effect of Albizia julibrissin Extracts |
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| HUA Hui,FENG Lei,ZHANG Xiao-ping,ZHANG Lian-fen,JIN Jian.The Study on the Anti-angiogenenic Effect of Albizia julibrissin Extracts[J].Natural Product Research and Development,2010,22(2):215-218. |
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| Authors: | HUA Hui FENG Lei ZHANG Xiao-ping ZHANG Lian-fen JIN Jian |
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| Institution: | HUA Hui1,FENG Lei1,ZHANG Xiao-ping1,ZHANG Lian-fen2,JIN Jian21Laboratory of Natural Medicine,School of Medicine , Pharmaceutics,Jiangnan University,2The Key Laboratory of Industrial Biotechnology,Ministry of Education,Wuxi 214122,China |
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| Abstract: | The anti-angiogenenic effect of Albizia julibrissin extracts was examined by the model of HMEC-1 in vitro,chick chorioallantoic membrance and cancer in vivo.The results showed that Albizia julibrissin extracts could significantly inhibit the proliferation and migration of HMEC-1 in a dose-dependent manner(IC_(50)=30 μg/mL).It also inhibited the angiogenesis in chick chorioallantoic membrance and cancer in vivo. |
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| Keywords: | Albizia julibrissin Durazz angiogenesis HMEC-1 |
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