Directed evolution and targeted mutagenesis to murinize listeria monocytogenes internalin A for enhanced infectivity in the murine oral infection model |
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| Authors: | Ian R Monk Pat G Casey Colin Hill Cormac GM Gahan |
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| Affiliation: | 1.Alimentary Pharmabiotic Centre & Department of Microbiology,University College Cork,Cork,Ireland;2.Alimentary Pharmabiotic Centre, Department of Microbiology & School of Pharmacy,University College Cork,Cork,Ireland;3.School of Genetics and Microbiology, Department of Microbiology,Trinity College Dublin,Ireland |
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| Abstract: | Background Internalin A (InlA) is a critical virulence factor which mediates the initiation of Listeria monocytogenes infection by the oral route in permissive hosts. The interaction of InlA with the host cell ligand E-cadherin efficiently stimulates L. monocytogenes entry into human enterocytes, but has only a limited interaction with murine cells. |
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