| 细胞膜转运分子ABCC3和SLC7A7在肠道病毒A71型感染中作用的初步研究 |
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| 引用本文： | 王嘉琪,胡栩策,刘延刚,陈生林,任浩,戚中田. 细胞膜转运分子ABCC3和SLC7A7在肠道病毒A71型感染中作用的初步研究[J]. 微生物与感染, 2021, 16(1): 10-18. DOI: 10.3969/j.issn.1673-6184.2021.01.002 |
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| 作者姓名： | 王嘉琪 胡栩策 刘延刚 陈生林 任浩 戚中田 |
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| 作者单位： | 海军军医大学微生物学教研室,上海市医学生物防护重点实验室,上海200433;海军军医大学教务处,上海200433;西藏军区总医院检验科,西藏自治区拉萨850007 |
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| 摘 要： | 肠道病毒A71型(enterovirus A71,EV-A71)是导致手足口病(hand-foot-mouth disease,HFMD)的主要病原体之一,目前对其治疗尚无特异高效的抗病毒药物.研究表明,细胞膜转运相关分子参与病毒的入侵、复制以及感染性子代病毒颗粒的释放.为寻找宿主中可有效抑制EV-A71感染的细胞膜转...
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| 关 键 词： | ATP结合盒转运蛋白C3 溶质载体家族7成员7 人结肠癌细胞(Caco-2) RNA干扰 肠道病毒A71型 |
Preliminary study on the role of membrane transport molecules ABCC3 and SLC7A7 in enterovirus A71 infection EV72 infection |
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| WANG Jiaqi,HU Xuce,LIU Yangang,CHEN Shenglin,REN Hao,QI Zhongtian. Preliminary study on the role of membrane transport molecules ABCC3 and SLC7A7 in enterovirus A71 infection EV72 infection[J]. Journal of Microbes and Infection, 2021, 16(1): 10-18. DOI: 10.3969/j.issn.1673-6184.2021.01.002 |
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| Authors: | WANG Jiaqi HU Xuce LIU Yangang CHEN Shenglin REN Hao QI Zhongtian |
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| Affiliation: | 1. Department of Medical Biodefense, Naval Military Medical University, Shanghai Key Laboratory of Medical Biodefense, Shanghai 200433, China; 2. Office of Academic Affairs, Naval Military Medical University, Shanghai 200433, China; 3. Department of Clinic Laboratory Diagnostics, General Hospital of Tibet Military Area Command of PLA, Lhasa 850007, Tibet, China |
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| Abstract: | Enterovirus A71 (EV-A71) is one of the main pathogens causing hand-foot-mouth disease (HFMD). There are no specific and effective antiviral drugs for the treatment of HFMD. Studies have shown that cell membrane transport molecules are involved in virus invasion, replication and the release of infectious virus particles. In order to find the host factors that can effectively inhibit EV-A71 infection, human colon cancer cells (Caco-2) were used as target cells, and RNA interference was used to downregulate the expression of transport-related membrane proteins. The data showed that ATP-binding cassette transport subfamily C member 3 (ABCC3) and solute carrier family 7 member 7 (SLC7A7) played important roles in EV-A71 infection in Caco-2 cells, which provided potential targets for the prevention and treatment of EV-A71 infection. |
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| Keywords: | ATP-binding cassette transporter subfamily C member 3 Solute carrier family 7 member 7 Human colon cancer cell (Caco-2) RNA interference Enterovirus A71 |
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