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Lymphocyte function in experimental African trypanosomiasis. IV. Immunosuppression and suppressor cells in the athymic nu/nu mouse
Authors:J M Mansfield  R F Levine  W L Dempsey  S R Wellhausen  C T Hansen
Affiliation:1. Department of Microbiology and Immunology, School of Medicine, University of Louisville Health Sciences Center, Louisville, Kentucky 40292 U.S.A.;2. Veterinary Resources Branch, National Institutes of Health, Bethesda, Maryland 20014 U.S.A.
Abstract:The role of T cells in the development and expression of antigen-nonspecific immunosuppression in experimental African trypanosomiasis was addressed. Nude (nunu) C57BL/ 6 NIH mice and their thymus-bearing (nu+) littermates were infected with Trypanosoma rhodesiense and examined for suppression of splenic B-cell responses in vitro to the mitogen LPS. All animals developed splenic unresponsiveness to LPS. Further, both nu/nu and nu/ + infected mice displayed suppressor cell activity in their spleen cell populations upon transfer to normal uninfected mouse spleen cell cultures. On the basis of these findings we suggest that both the generalized immunosuppression and the development of suppressor cell activity in the spleens of mice infected with T. rhodesiense are T-independent processes.
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