CD8+ lymphocytes suppress HIV production by autologous CD4+ cells without eliminating the infected cells from culture |
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| Authors: | L D Wiviott C M Walker J A Levy |
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| Affiliation: | Department of Medicine, University of California, School of Medicine, San Francisco 94143. |
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| Abstract: | Studies of separated peripheral blood mononuclear cell subsets have indicated that the CD8+ lymphocyte is the primary cell type responsible for suppressing human immunodeficiency virus (HIV) replication by infected CD4+ cells. The effect of this antiviral activity is dose-dependent and does not involve killing of the infected cell. These observations indicate that this response is distinct from the anti-HIV cytotoxic mechanisms also described for human CD8+ cells. |
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