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Potent and selective CC-chemokine receptor-2 (CCR2) antagonists as a potential treatment for asthma |
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| Authors: | Lagu Bharat Gerchak Chrissy Pan Meng Hou Cuifen Singer Monica Malaviya Ravi Matheis Michele Olini Gil Cavender Druie Wachter Michael |
| Affiliation: | Johnson & Johnson Pharmaceutical Research and Development, Cranbury, NJ 08512, USA. bharat.lagu@novartis.com |
| Abstract: | A number of compounds bearing a quaternary ammonium moiety were found to be antagonists with nanomolar binding affinity for the chemokine receptor-2. The structure-activity relationships in the series are described herein along with some detailed characterization of the interesting compounds. |
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