Somatostatin induces rapid contraction of neuroendocrine cells |
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Authors: | Saras Jan Grönberg Malin Stridsberg Mats Oberg Kjell E Janson Eva T |
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Affiliation: | Department of Medical Sciences, Section of Endocrine Oncology, Uppsala University Hospital, Uppsala, Sweden. jan.saras@medsci.uu.se |
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Abstract: | The peptide hormone somatostatin, as well as the somatostatin analog octreotide, induces rapid morphological changes in neuroendocrine cells. The effect can be detected in less than 2 min: retraction fibers are formed, cells round up and cell-cell contacts are broken. Somatostatin-dependent cell contraction is inhibited by Y-27632, indicating that this effect is dependent on Rho kinase. In BON1 cells, the somatostatin-induced inhibition of forskolin-induced secretion of chromogranin A is not blocked by Y-27632. It is therefore concluded that the inhibitory effect of somatostatin in forskolin-stimulated cells is not dependent on cell contraction. |
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Keywords: | Somatostatin Actin cytoskeleton Cell contraction Secretion Rho kinase |
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