Polysaccharides isolated from liquid culture broth of Inonotus obliquus inhibit the invasion of human non-small cell lung carcinoma cells |
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Authors: | Jong Seok Lee Ki Rim Lee Sarah Lee Hye Jin Lee Hee-sun Yang Joohong Yeo Jun Myoung Park Byung Hyun Choi Eock Kee Hong |
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Affiliation: | 1.Department of Bioengineering and Technology,Kangwon National University,Chuncheon,Korea;2.National Institute of Biological Resources,Incheon,Korea |
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Abstract: | Polysaccharides isolated from Inonotus obliquus (PLIO) have been known to have various pharmacological activities including antioxidant, immunostimulating and anti-tumor activity. However, the anti-metastatic effect of PLIO in human non-small cell lung carcinoma (NSCLC) has not been elucidated. In this study, we investigated the effects of PLIO on the metastatic potential of human NSCLC A549 cells and its underlying mechanisms. PLIO suppressed the invasive potential of A549 cells throughout reducing matrix metalloproteinase (MMP) expression. PLIO treatment inhibited NF-κB nuclear translocation in A549 cells. In addition, PLIO treatment inhibited the phosphorylation of JNK/AKT in A549 cells. These results suggest that PLIO could inhibit human NSCLC invasion via suppression of AKT/NF-κB signaling pathway. |
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