Use of Nanoscale Materials for the Effective Prevention and Extermination of Bacterial Biofilms |
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| Authors: | Dohyun Lee Youngmin Seo Muhammad Saad Khan Jangsun Hwang Yeonho Jo Jaewoo Son Kyungwoo Lee Chanhwi Park Sachin Chavan Assaf A Gilad Jonghoon Choi |
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| Institution: | 1.School of Integrative Engineering,Chung-Ang University,Seoul,Korea;2.Center for Biomaterials, Biomedical Research Institute,Korea Institute of Science and Technology,Seoul,Korea;3.Russell H. Morgan Department of Radiology and Radiological Health,Johns Hopkins University School of Medicine,Baltimore,USA;4.Cellular Imaging Section, Institute for Cell Engineering,Johns Hopkins University School of Medicine,Baltimore,USA |
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| Abstract: | Biofilms have been shown to cause most human infections. The prevention and extermination of bacterial biofilms has always presented a major challenge in the clinic. The failure of traditional antibiotics and the development of bacterial resistance against these measures is on the rise. Nanoscale materials possess the advantage of presenting enhanced surface properties of bulk materials, and are emerging as effective agents for deterring microbial growth. This review article summarizes the fundamentals of bacterial growth, biofilm formation, mechanisms for antibacterial technologies, and usage of nanoparticles for the prevention and extermination of biofilms. Further research is required with respect to the appropriate usage of nanoparticles for the effective control of biofilms to save human lives and reduce healthcare costs. |
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