Evaluation of flavonoids from Zostera asiatica as antioxidants and nitric oxide inhibitors |
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| Authors: | Hojun Kim Huijeong Jeong Joo Wan Hong Eunshin Ju Chang-Suk Kong Youngwan Seo |
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| Affiliation: | 1.Division of Marine Bioscience, College of Ocean Science and Technology,Korea Maritime and Ocean University,Busan,Korea;2.Department of Convergence Study on the Ocean Science and Technology, Ocean Science and Technology School,Korea Maritime and Ocean University,Busan,Korea;3.Department of Food and Nutrition, College of Medical and Life Sciences,Silla University,Busan,Korea;4.Marine Biotechnology Center for Pharmaceuticals and Foods,Silla University,Busan,Korea |
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| Abstract: | Zostera asiatica is one of the five members of the genus Zostera that can be found in Korea. Studies have reported the phytochemical properties and bioactivities of Zostera species. Current study focused on the antioxidant effects of Z. asiatica as a part of ongoing research for bioactive substances from marine resources. Results indicated that a crude extract of Z. asiatica not only scavenged on peroxynitrite in vitro and on intracellular reactive oxygen species (ROS) but also inhibited production of nitric oxide (NO). The crude extract was subjected to solvent fractionation for bioactivity-based separation using aforementioned three bioassay systems. From the active n-butanol fraction, two flavonoids were isolated and characterized as luteolin (1) and luteolin-3’-sulfate (2). Both flavonoids showed significant antioxidant effects. In conclusion, Z. asiatica was demonstrated to possess antioxidant effect partly attributed to isolated flavonoids, the first such effect reported from Z. asiatica, to the best of our knowledge. |
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