5-Hydroxytryptophol in Human Cerebrospinal Fluid: Conjugation, Concentration Gradient, Relationship to 5-Hydroxyindoleacetic Acid, and Influence of Hereditary Factors |
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Authors: | Olof Beck,Stefan Borg&dagger ,Gunnar Edman&Dagger ,Bengt Fyrö &Dagger ,Gabriella Oxenstierna&Dagger ,Gö ran Sedvall&Dagger |
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Affiliation: | Department of Toxicology, Karolinska Institute, Stockholm, Sweden;Department of Psychiatry, St. Görans Hospital, Karolinska Institute, Stockholm, Sweden;Laboratory of Experimental Psychiatry, Department of Psychiatry, Karolinska Institute, Stockholm, Sweden |
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Abstract: | The serotonin metabolite 5-hydroxytryptophol was studied in human cerebrospinal fluid. A minor fraction (approximately 13%) was found in conjugated form from which it was liberated by treatment with sulphatase containing beta-glucuronidase activity. A concentration gradient of 5-hydroxytryptophol concentration was shown on lumbar tapping and the concentration in ventricular CSF was about 2.5 times higher than that in lumbar CSF. 5-Hydroxytryptophol and 5-hydroxyindoleacetic acid concentrations were significantly correlated in healthy, psychotic, and depressed subjects, but not in alcoholics. 5-Hydroxytryptophol concentrations in CSF of psychotic and depressed subjects were not different from those of healthy controls (4.22 pmol/ml +/- 0.15, SEM). In healthy subjects, hereditary factors seemed to have little influence on the CSF level of 5-hydroxytryptophol. |
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Keywords: | Cerebrospinal fluid 5-Hydroxytryptophol 5-Hydroxyindoleacetic acid |
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