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Tet2 Regulates Osteoclast Differentiation by Interacting with Runx1 and Maintaining Genomic 5-Hydroxymethylcytosine (5hmC)
Authors:Yajing Chu  Zhigang Zhao  David Wayne Sant  Ganqian Zhu  Sarah M Greenblatt  Lin Liu  Jinhuan Wang  Zeng Cao  Jeanette Cheng Tho  Shi Chen  Xiaochen Liu  Peng Zhang  Jaroslaw P Maciejewski  Stephen Nimer  Gaofeng Wang  Weiping Yuan  Feng-Chun Yang  Mingjiang Xu
Institution:1. State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, China;2. Department of Hematology and Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China;3. Department of Oncology, The Second Affiliated Hospital of Tianjin Medical University, Tianjin 300211, China;4. Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA;5. Department of Human Genetics, University of Miami Miller School of Medicine, Miami, FL 33136, USA;6. Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33136, USA;7. Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA;8. Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH 44195, USA
Abstract:
Keywords:Tet2  5hmC  Macrophage  Osteoclast  Runx1
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