Intra-amniotic prostaglandin F2α and urea for abortion |
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Authors: | Ian Craft Elizabeth Walker Ezat Youssefnejadian |
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Institution: | Institute of Obstetrics and Gynecology, Chelsea Hospital for Women, London, SW3 England |
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Abstract: | Prostaglandin F2α (PGF2α) 20 mg combined with urea 80 g was injected intra-amniotically in 20 patients to induce mid-trimester abortion. Abortion resulted in all subjects within 24 hours in a mean time of 12 hours 38 minutes (range 5 hours 50 minutes to 20 hours 45 minutes).Plasma sex steroids were evaluated before and hourly for 5 hours after the injection. A progressive decline in levels occurred with time. Decreases in plasma progesterone, estrone, estradiol and estriol were significant as soon as one hour after injection.Gastrointestinal side effects occurred with a greater frequency than when a comparable dose of PGF2α is given alone and 2 patients had small cervical lacerations requiring suture. Further studies are indicated to establish whether a lower dose of PGF2α will be associated with fewer side effects and be as effective. |
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