Increased Expression of Several Mitochondrial Genes in Human and Monkey B-Cell Non-Hodgkin Lymphomas |
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| Authors: | Nikolaev A I Martynenko A V Kalmyrzaev B B Inozemtseva L I Dubovaya V I Hunsmann G Bodemer B Tarantul V Z |
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| Institution: | (1) Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, 123182, Russia;(2) Deutsches Primatenzentrum, Goettingen, Germany |
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| Abstract: | Mitochondrial genes overexpressed in human and monkey B-cell non-Hodgkin lymphomas (B-NHLs) were sought via subtraction hybridization, cloning, and differential screening of the resulting cDNA libraries. The cDNAs of mitochondrial genes constituted an appreciable proportion of all lymphoma-specific cDNAs. Lymphomogenesis was associated with upregulation of a set of mitochondrial genes, which varied with lymphoma type but always included NADHIV. A possible association between upregulation of certain mitochondrial genes and cell malignant transformation is discussed. |
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| Keywords: | malignant transformation differential gene expression lymphomogenesis mitochondria mitochondrial genome apoptosis |
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