Diabetes Mellitus as a Risk Factor for Open-Angle Glaucoma: A Systematic Review and Meta-Analysis |
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| Authors: | Minwen Zhou Wei Wang Wenbin Huang Xiulan Zhang |
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| Affiliation: | 1. Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, People''s Republic of China.; 2. Department of Ophthalmology, Shanghai First People''s Hospital, School of Medicine, Shanghai JiaoTong University, Shanghai, China.; 3. Shanghai Key Laboratory of Fundus Disease, Shanghai, China.; Massachusetts Eye & Ear Infirmary, Harvard Medical School, United States of America, |
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| Abstract: | ObjectiveTo determine the association between diabetes mellitus (DM) and primary open-angle glaucoma (POAG).MethodsThis is a systematic review and meta-analysis of case-control and cohort studies. The literature search included two databases (PubMed and Embase) and the reference lists of the retrieved studies. Separate meta-analyses for case-control studies and cohort studies were conducted using random-effects models, with results reported as adjusted odds ratios (ORs) and relative risks (RRs), respectively.ResultsThirteen studies—seven case-control studies and six population-based cohort studies—were included in this meta-analysis. The pooled RR of the association between DM and POAG based on the risk estimates of the six cohort studies was 1.40 (95% CI, 1.25–1.57). The pooled OR of the association between DM and POAG based on the risk estimates of the seven case-control studies was 1.49 (95% CI, 1.17–1.88). There was considerable heterogeneity among the case-control studies that reported an association between DM mellitus and POAG (P<0.001) and no significant heterogeneity among the cohort studies (P = 0.377). After omitting the case-control study that contributed significantly to the heterogeneity, the pooled OR for the association between DM and POAG was 1.35 (95% CI, 1.06–1.74).ConclusionsIndividuals with DM have an increased risk of developing POAG. |
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