Centrosomal protein 55: A new paradigm in tumorigenesis |
| |
| Affiliation: | 1. Departments of Cell, Developmental and Cancer Biology, Oregon Health and Science University, Portland, Oregon, USA;2. Biomedical Engineering, Oregon Health and Science University, Portland, Oregon, USA;3. Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon, USA;1. Lee Kong Chian School of Medicine, Nanyang Technological University, 59 Nanyang Drive, Singapore 636921, Singapore;2. Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Dag Hammarskölds väg 20, Uppsala Se-751 85, Sweden;3. Institute of Radiochemistry and Radioecology, University of Pannonia, Egyetem u. 10, H-8200 Veszprém, Hungary;4. Department of Biophysics and Radiation Biology, Semmelweis University Faculty of Medicine, Tűzoltó u. 37-47, Budapest H-1094, Hungary;1. Department of Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran;2. Department of Genetic Medicine and Development, iGE3 and Centre Facultaire du Diabète, Faculty of Medicine, University of Geneva, Geneva, Switzerland;3. Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran;4. Department of Diabetes, Obesity, and Metabolism, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran;5. Department of Developmental Biology, University of Science and Culture, Tehran, Iran |
| |
| Abstract: | Centrosomal Protein 55 (Cep55), also known as c10orf3 and FLJ10540, was initially discovered as a major player in abscission, the final stage of cytokinesis. Subsequent studies have described its role in regulating the PI3K/AKT pathway, increasing cancer cell stemness, and promoting tumor formation. Clinically, Cep55 has been found to be overexpressed in many cancer types. Cep55 overexpression has been notably associated with tumor stage, tumor aggressiveness, poor prognosis, and metastasis. The present review discusses the role of Cep55 as a crucial biomarker and model in tumorigenesis. |
| |
| Keywords: | Cep55 Cytokinesis Abscission Cancer Biomarker ESCRT |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
