Structural characterization of a blood group A heptaglycosylceramide with globo-series structure. The major glycolipid based blood group A antigen of human kidney |
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| Authors: | M E Breimer P A Jovall |
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| Affiliation: | 1. Department of Surgery I, University of Göteborg, Sahlgrens Hospital, 413 45 Göteborg, Sweden;2. Department of Medical Biochemistry, University of Göteborg, PO Box 33031, S-400 33 Göteborg, Sweden;3. Department of Biochemistry, University of Göteborg and Chalmers Institute of Technology, S-412 96 Göteborg, Sweden |
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| Abstract: | A blood group A glycosphingolipid with the globo-series structure has been isolated from human kidney and structurally characterized. The structure was shown by mass spectrometry and proton NMR spectroscopy of the intact permethylated and permethylated-reduced derivatives together with degradation studies to be, GalNAc alpha 1----3Gal(2----1 alpha Fuc)beta 1----3GalNAc beta 1----3Gal alpha 1----4Gal beta 1----4Glc beta 1----1 Ceramide. This glycolipid reacts with both polyclonal and monoclonal anti-A blood group typing antisera and it is the major glycolipid based blood group A antigen present in the human kidney. |
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