Clinical experience of targeted therapy |
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Authors: | Hans-Georg Eichler |
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Affiliation: | (1) Division of Clinical Pharmacology, 1. Medizinische Universitätsklinik, Vienna University School of Medicine, Lazarettgasse 14, A-1090, Vienna, Austria |
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Abstract: | Drug targeting (i.e. administration of a drug-carrier conjugate which delivers active drug selectively to a particular tissue) has recently evolved into a new subdiscipline of experimental pharmacy/pharmacology. However, clinical experience with targeted therapy is very limited to date. This review summarizes human studies of targeted therapy. Indications for which drug targeting has been attempted include neoplastic disorders, fungal infections, enzyme replacement, hematologic and immune disorders, and iron storage disease. To date, no single drug targeting system is recommendable for routine clinical use, but present results justify further clinical evaluation in a number of situations. |
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Keywords: | drug targeting drug carrier drug delivery liposomes immunoconjugates polynucleotides drug carrier erythrocytes lysosomotropic therapy human studies |
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