Molecular footprints of human immunoglobulin gene evolution: a new sequence family. |
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| Authors: | B Straubinger M Pech K Mühlebach H R Jaenichen H G Bauer and H G Zachau |
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| Institution: | B Straubinger, M Pech, K Mühlebach, H R Jaenichen, H G Bauer, and H G Zachau |
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| Abstract: | Analysis of the human VK (ref. 2) gene locus led to the detection of a new sequence family (L sequences). Its copy number is in the range of 10(2). The L sequences, which are about 500 bp long, are found as part of the 3' flanking regions of a clustered set of human VKI genes but they occur also separate from the genes. Models are discussed in which L sequences are viewed as molecular footprints of amplification and transposition processes of VK genes. |
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