Annexins and endocytosis |
| |
Authors: | Futter Clare E White Ian J |
| |
Affiliation: | Institute of Ophthalmology, University College, London, 11-43 Bath Street, London EC1V 9EL, UK. c.futter@ucl.ac.uk |
| |
Abstract: | Annexins are calcium- and phospholipid-binding proteins that have been proposed to have multiple roles in membrane traffic. Historically, this has been based on the in vitro properties of annexins and their localization to specific membrane compartments. However, recent functional evidence supports a role for annexins in specific membrane traffic steps, although the requirement for annexins may be highly dependent on the cellular context. Here we review the roles of annexins in traffic within the endocytic pathway, focusing on clathrin-dependent internalization from the plasma membrane, multivesicular endosome/body (MVB) biogenesis and MVB-lysosome fusion. |
| |
Keywords: | annexin clathrin lysosome multivesicular body |
本文献已被 PubMed 等数据库收录! |
|