Effect of aging on neurotransmitter receptor binding in rat and human brain. |
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| Authors: | A Maggi M J Schmidt B Ghetti S J Enna |
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| Affiliation: | 1. Departments of Pharmacology and of Neurobiology and Anatomy, University of Texas Medical School at Houston, P.O. Box 20708, Houston, Texas 77025, USA;2. Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46206, USA;3. Department of Neuropathology, Indiana University Medical Center, Indianapolis, Indiana 46202, USA |
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| Abstract: | β-Adrenergic and GABA receptor binding were measured in brain areas of rats 3 to 24 months of age. While GABA receptor binding was not significantly different across age in any area, β-adrenergic receptor binding was significantly reduced in the cerebellum and brain stem, but not cerebral cortex, of 24-month-old animals. The loss in β-adrenergic receptor binding does not correlate in a temporal fashion with the reported decrease in norepinephrine-stimulated cyclic AMP accumulation in the cerebellum which occurs as early as 12 months of age. An age-related reduction in β-adrenergic binding was also noted in human cerebellar tissue obtained at autopsy, suggesting that the cerebellar dysfunction seen with aging may be related to a loss of cerebellar neurons which receive noradrenergic input. |
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| Keywords: | To whom correspondence should be addressed. |
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