Evolutionary relationship between human and mouse immunoglobulin kappa light chain variable region genes |
| |
Authors: | Guido Kroemer Arno Helmberg Alain Bernot Charles Auffray Reinhard Kofler |
| |
Affiliation: | (1) Institut d'Embryologie du CNRS et du Collège de France, Nogent-sur-Marne, France;(2) Centro de Biología Molecualr, CSIC, Universidad Autónoma, Madrid, Spain;(3) Institute for General and Experimental Pathology, University of Innsbruck Medical School, Innsbruck, Austria;(4) Centro de Biología, Molecular, CSIC, Universidad Autónoma, Campus de Cantoblanco, 28049 Madrid, Spain |
| |
Abstract: | Similar to the Igh-V multigene family, the human or mouse Igk-V repertoirer is a distorted continuum of homologous genes that may be grouped into families displaying >80% nucleic acid sequence similarity among their members. systematic interspecies sequence comparisons reveal that most human Igk-V gene families exhibit clear homology to mouse Ogk-V families (sequence similarity >74%). A hypothetical phylogenetic tree of Igk-V genes predicts that a minimum of seven Igk-V genes/families predate mammalian radiation. In two cases, several interrelated mouse Igk-V families exhibit phylogenetic equidistance with just one human Igk-V family, implying a more pronounced divergence for the elevated number of Igk-V gene families in the mouse. Mouse-human Igk-V comaprisons, moreover, illustrate how expansion, contraction, and perhaps deletion of Igk-V gene families shape the Igk-V repertoire during mammalian evolution. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|